MOVE

Assessment of brain maturation by brain connectivity in human neonates

Analysis of brain connectivity through different signal analysis methods is an active research field both in basic and clinical neurophysiology. In this talk we present results on the application of nonlinear time series methods to the EEG of healthy human neonates (both term and preterm) and find that there exist differences in the degree of brain maturation between both groups. However, the time spent outside maternal uterus seems to play a more important role that the total PMA. On the other hand, we also present results of the analysis of the interdependence between EEG activity in different frequency bands and respiratory and heart rate activity, which suggest that the course of this interdependence during the earliest stage of life can be also studien by this approach. We finally discuss the clinical implications of these outcomes.