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dr. R.T. de Jongh (Renate)

VU University Medical Center
Department of Endocrinology
Boelelaan 1117
1081 HV Amsterdam
Tel: +31 (20) 4440502
Email: RT.deJongh@vumc.nl

Research interests

My main interest is in research related to vitamin D and bone metabolism and diseases.

Within the Longitudinal Aging Study Amsterdam, on ongoing Dutch population-base cohort study, I’m involved in studies related to prediction of vitamin D levels and potential effects associated with vitamin D deficiency. Also, we are currenlty performing a randomized controlled trial after the effects of vitamin D suppletion in patients with chronic obstructive pulmonary disease.

Currently, another research topic of my interest lies in osteoporosis and fracture risk. In the VU University Medical Center there is a special outpatient clinic since 2005 to identify patients with osteoporosis and othe reasons for a high fracture risk after presentation with a fracture, the “Osteoporosis and fracture clinic”. We will perform studies in the database of this clinic to examine several research questions such as the prevalence of secundary osteoporosis.


E , N van Schoor, R de Jongh, OJ de Vries, P Lips. The impact of medication on vitamin D status in older individuals. Eur J Endocrinol. 2011; Epub ahead of print.

E Pijpers, I Ferreira, RT de Jongh, DJ Deeg, P Lips, CD Stehouwer, AC Nieuwenhuijzen Kruseman. Older individuals with diabetes have an increased risk of recurrent falls: analysis of potential mediating factors: the Longitudinal Ageing Study Amsterdam. Age Ageing. 2011; Epub ahead of print.

RT de Jongh, P Lips, NM van Schoor, KJ Rijs, DJ Deeg, HC Comijs, MH Kramer, JP Vandenbroucke, OM Dekkers. Endogenous subclinical thyroid disorders, physical and cognitive function, depression, and mortality in older individuals. Eur J Endocrinol. 2011;165:545-54.

RT de Jongh, P Lips, KL Rijs, NM van Schoor, MH Kramer, JP Vandenbroucke, Dekkers OM. Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals. Eur J Endocrinol. 2011;164:75-82.

IJ Ketel, CD Stehouwer, EH Serné, TJ Korsen, PG Hompes, YM Smulders, RT de Jongh, R Homburg, CB Lambalk. Obese but not normal-weight women with polycystic ovary syndrome are characterized by metabolic and microvascular insulin resistance. J Clin Endocrinol Metab. 2008; 93:3365-3372.

RG IJzerman, RT de Jongh, EH Serné. Commentary on viewpoint: the human cutaneous circulation as a model of generalized microvascular function. J Appl Physiol. 2008;105:378.

MP de Boer, RG IJzerman, RT de Jongh, EC Eringa, CD Stehouwer, YM Smulders, EH Serné. Birth weight relates to salt sensitivity of blood pressure in healthy adults. Hypertension 2008;51:928-32.

RT de Jongh, EH Serné, RG IJzerman, H Thune Jørstad, CDA Stehouwer. Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women Microvasc Res. 2008;75:256-62.

RT de Jongh, EH Serné, RG IJzerman, CDA Stehouwer. Microvascular function: A potential link between salt sensitivity, insulin resistance and hypertension. J Hypertens 2007;25:1887-1893.

AM Jonk, AJ Houben, RT de Jongh, EH Serné, NC Schaper, CD Stehouwer. Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension. Physiology 2007;22:252-60.

EH Serné, RT de Jongh, EC Eringa, RG IJzerman, CD Stehouwer. Microvascular dysfunction: a potential pathophysiological role in the metabolic syndrome. Hypertension 2007;50:204-11.

RT de Jongh, RG IJzerman, EH Serné, MM van Weissenbruch, JJ Voordouw, HA Delemarre-van de Waal, CD Stehouwer. Urinary cortisol is inversely associated with capillary recruitment in women: a potential explanation for the cortisol-blood pressure relationship. Clin Sci 2007;113:83-91.

EH Serné, RT de Jongh, EC Eringa, RG IJzerman, MP de Boer, CD Stehouwer. Microvascular dysfunction: causative role in the association between hypertension, insulin resistance and the metabolic syndrome? Essays Biochem 2006;42:163-76.

RT de Jongh, RG IJzerman, EH Serné, JJ Voordouw, JS Yudkin, HA Delemarre-van de Waal, CD Stehouwer, MM van Weissenbruch. Visceral and truncal subcutaneous adipose tissue are associated with impaired capillary recruitment in healthy individuals. J Clin Endocrinol Metab 2006;91:5100-6.

RT de Jongh, EH Serné, EC Eringa, RG Ijzerman, CDA Stehouwer. Does microvascular dysfunction link obesity with insulin resistance and hypertension? Exp Rev Endocrinol Metab 2006;1:181-87. (no IF, start of publication in 2006)

RT de Jongh, EH Serné, RG IJzerman, G de Vries, CD Stehouwer CD. Free fatty acid levels modulate microvascular function: relevance for obesity-associated insulin resistance, hypertension, and microangiopathy. Diabetes 2004; 53:2873-82.

RT de Jongh, ADH Clark, RG IJzerman, EH Serné, G de Vires, CDA Stehouwer. Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers. Diabetologia 2004;47:978-86.

RT de Jongh, EH Serné, RG IJzerman, G de Vries, CDA Stehouwer. Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension and insulin resistance. Circulation 2004;109:2529-35.

MT Schram, F Stam, RT de Jongh, G Vries, RA van Dijk, EH Serné, D Lampe, P Nanayakkara, ME Tushuizen, PG Scheffer, CG Schalkwijk, AM Kamper, CD Stehouwer. The effect of calcium dobesilate on vascular endothelial function, blood pressure, and markers of oxidation in obese male smokers: a placebo-controlled randomised clinical trial. Atherosclerosis. 2003;170(1):59-72.

RG IJzerman, RT de Jongh, MA Beijk, MM van Weissenbruch, HA Delemarre-van de Waal, EH Serné, CD Stehouwer. Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin. Eur J Clin Invest. 2003;33:536-42.

RG IJzerman, EH Serné, MM van Weissenbruch, RT de Jongh, CD StehouwerD. Cigarette smoking is associated with an acute impairment of microvascular function in humans. Clin Sci 2003 ;104:247-52.

EH Serné, RG IJzerman, RT de Jongh, CDA Stehouwer. Blood pressure and insulin resistance: Role for microvascular function? (letter) Cardiovasc Res 2002;55:418-419.


Medical degree, Vrije Universiteit Medical Center Amsterdam, February 2001; cum laude

Doctorate, Vrije Universiteit Amsterdam, November 2007, Title of thesis: Microvascular dysfunction: metabolic and cardiovascular causes and consequences

Specialisation in Internal Medicine and Endocrinology, Vrije Universiteit Medical Center, December 2010

Master in epidemiology, Vrije Universiteit Amsterdam, June 2011

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