MOVE

The aim of the research is to prevent or recover damage to the motor system, due to disposition, ageing, inadequate nutrition, incorrect movement or loading habits. This is found in patients with osteoporosis, arthrosis and discus degeneration, as well as in patients with damaged bone, cartilage or muscle tissues. Tissue regeneration will be possible by means of mechanical loading and through growth factors, hormones and medication. A very important future tool for the regeneration of tissue will be the use of stem cells which are able to differentiate in bone, cartilage and muscle cells. This will be achieved by comparing results from tissue culture and animal models to computer simulations of the motor system and to biomechanical research in clinical trials with patients.

Staff

Current projects

• Effects of strontium renalate on the response of osteocytes to mechanical loading and osteocyte-signaling towards osteoclasts and osteoblasts
  Bakker, Klein-Nulend
• Myofibroblasts
  Blaauboer, Smit, Everts
• Immunohistochemistry of estrogen receptors alpha and beta on bone biopsies of patients treated with raloxifene
  Bravenboer, Lips
• Studies on the regeneration of nucleus pulposus using biomimetic scaffolds
  Detiger, van Royen, Helder, Smit
• Implementation of a strategy of osteoporosis screening in patients over 50 years of age with a first fracture, with intensive treatment and follow-up by a nurse-practitioner to prevent recurrent fractures in those patients with diagnosed osteoporosis
  Eekman, Lems
• Quantification of spinal segment stiffness: a clinical tool for evaluating disc degeneration
  van Engelen, van Dieën, van Royen, Smit
• Protection of osteocytes against apoptosis
  van Essen, Bravenboer, Lips
• PDEE-sandwich
  Everts, Belucci
• The role of citokines, macrophages and fibroblasts in skin and mucosal scar formation
  Glim, Niessen
• Cellular responses to mechanical loading: an in vitro model for splinting regimes
  Contracts
  Gouveneur, Smit, Middelkoop
• Attachment and differentiation profiles of human bone marrow and adipose tissue stem cell preparations on ChronOS strips
  Helder, Smit, Kroeze
• Somatic and reprogrammed stem cells for treatment of bone growth disorders: epigenetic basis of cell identity and control
  Holmes, Klein-Nulend, Pals
• Influence of muscle use on bone adaptation
  de Jong, Langenbach
• Biological pathways for regulation of muscle fiber size and bone mass
  Juffer, Bakker, Jaspers, Klein-Nulend, Lips
• Directing adipose derived stem cells to the area at risk in the heart after myocardial infarction using targeted microbubbles. Development of a new molecular therapeutic technique
  Juffermans, Helder
• Cartilage regeneration with adipose tissue derived stem cells
  Jurgens, Ritt, Helder
• Physical principles in the embryonic development of the spine: How initial pattern formation leads to differential tissue development
  Klumpers, Smit
• Heterogeneity in the human mandibular condyle
  Koolstra, van Ruijven
• Effects of delayed-onset muscle soreness on the sensorimotor control of the masticatory system
  Koutris, Naeije, Lobbezoo
• Injectable biomaterials as stem cell carriers for intervertebral disc tissue engineering
  Kroeze, Bank, Helder, Smit
• Attachment and differentiation profiles of human bone marrow and adipose tissue stem cell preparations on ChronOS strips
  Kroeze, Helder, Smit
• Bone adaptation and regeneration – intercellular communication between osteocytes and osteoclasts
  Kulkarni, Klein-Nulend
• Bone, estrogen and mechanical loading
  Lips, Bravenboer
• IGF I Expression in bone biopsies of growth hormone (GH) deficient patients
  Lips, Bravenboer
• The effect of renal transplantation on bone mass and bone metabolism in renal insufficiency patients
  Lips, Bravenboer
• Quality of life in osteoporosis
  Lips, van Schoor
• The role of macrophages in excessive scarring of the burned skin
  Mahdavian Delavary, Niessen
• Extrarenal hydroxylation of 25-hydroxyvitamin D
  van der Meijden, Bravenboer, Lips
• Validation of a model for an ex vivo organ culture of the intervertebral disc under dynamic loading conditions
  Mullender, Smit, Helder, van der Veen
• Role of inflammation factors in postfracture osteoporosis and rheumatoid arthritis and Crohn’s disease induced-osteoporosis
  Oostlander, Lips, Bravenboer, Klein-Nulend, Lems
• Bone augmentation with autologous mesenchymal stem cells from adipose tissue, BMP-2, and calcium phosphate carrier materials in the sinusfloor elevation model
  Overman, Schulten, Helder, ten Bruggenkate, Klein-Nulend
• The etiology of generalized osteoporosis in rheumatoid arthritis
  Pathak, Klein Nulend, Luiten (Leuven)
• Validation of a model for an ex vivo organ culture of the intervertebral disc under dynamic loading conditions
  Paul, Mullender, Smit, Helder, van der Veen
• Bone augmentation with autologous adipose tissue-dericed mesenchymal stem cells, BMP-2, and calcium phosphate carrier in the human maxillart sinus
  Prins, Klein-Nulend, ten Bruggenkate, Helder, Schulten
• Consequences of mechanical interaction between cartilage and bone for development of osteoarthrosis
  Renders, Koolstra
• Scaffold molding by CAD-CAM and targeting osteogenic differentiation of mesenchymal stem cells by mechanical loading in a 3D environment: Implications for oral and maxillofacial bone defects
  van der Rhee, Klein Nulend, Kleverlaan, Bakker, Forouzanfar
• Future Functional Status in Osteoarthritis of the Knee: Impact of Neuromuscular, Psychological and Clinical
  Sanchez Ramirez, Lems and Verschueren (Leuven)
• Treatment and prevention of low back pain by early, minimally invasive, functional treatment of intervertebral disc disease
  Smit, van der Veen, Abell
• Spinal fusion with soft-edged flexible cages: Biomechanical, Radiological and Histological Studies
  Smit, van der Veen, Paalman
• Fluid flow in the intervertebral disc
  Smit, Mullender, van der Veen
• The role of muscle function on ‘internal derangements’ of the TMJ
  Tuijt, Koolstra, Lobbezoo, Naeije
• Clinical evaluation of the Articulinx Device for the carpometacarpal joint
  van der Veen, Ritt
• IDiDAS – New early therapies for Intervertebral Disc Diseases (consortium)
  van der Veen, Smit, Paul, Mullender, Helder
• The relation between chewing, cognition and depression in older persons with a dementia
  Weijenberg, Scherder, Lobbezoo
• Combined effect of physical activity and nutrition on bone metabolism
  Willems, Klein-Nulend
• Development of architecture and mineralization of cortical and trabecular bone of the mandible
  Willems, Langenbach, Everts
• Sleep Bruxism: contemporary insights in diagnosis, etiology, and management
  van der Zaag, Naeije, Lobbezoo